Ontology highlight
ABSTRACT:
SUBMITTER: Dunaevsky A
PROVIDER: S-EPMC23966 | biostudies-literature | 1999 Nov
REPOSITORIES: biostudies-literature
Dunaevsky A A Tashiro A A Majewska A A Mason C C Yuste R R
Proceedings of the National Academy of Sciences of the United States of America 19991101 23
The function of dendritic spines, postsynaptic sites of excitatory input in the mammalian central nervous system (CNS), is still not well understood. Although changes in spine morphology may mediate synaptic plasticity, the extent of basal spine motility and its regulation and function remains controversial. We investigated spine motility in three principal neurons of the mouse CNS: cerebellar Purkinje cells, and cortical and hippocampal pyramidal neurons. Motility was assayed with time-lapse im ...[more]