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The glomerular transcriptome and a predicted protein-protein interaction network.


ABSTRACT: To increase our understanding of the molecular composition of the kidney glomerulus, we performed a meta-analysis of available glomerular transcriptional profiles made from mouse and man using five different methodologies. We generated a combined catalogue of glomerulus-enriched genes that emerged from these different sources and then used this to construct a predicted protein-protein interaction network in the glomerulus (GlomNet). The combined glomerulus-enriched gene catalogue provides the most comprehensive picture of the molecular composition of the glomerulus currently available, and GlomNet contributes an integrative systems biology approach to the understanding of glomerular signaling networks that operate during development, function, and disease.

SUBMITTER: He L 

PROVIDER: S-EPMC2396740 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature

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The glomerular transcriptome and a predicted protein-protein interaction network.

He Liqun L   Sun Ying Y   Takemoto Minoru M   Norlin Jenny J   Tryggvason Karl K   Samuelsson Tore T   Betsholtz Christer C  

Journal of the American Society of Nephrology : JASN 20071121 2


To increase our understanding of the molecular composition of the kidney glomerulus, we performed a meta-analysis of available glomerular transcriptional profiles made from mouse and man using five different methodologies. We generated a combined catalogue of glomerulus-enriched genes that emerged from these different sources and then used this to construct a predicted protein-protein interaction network in the glomerulus (GlomNet). The combined glomerulus-enriched gene catalogue provides the mo  ...[more]

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