Ontology highlight
ABSTRACT:
SUBMITTER: Engelsma D
PROVIDER: S-EPMC2397317 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20080402 6
CRM1 exports proteins that carry a short leucine-rich peptide signal, the nuclear export signal (NES), from the nucleus. Regular NESs must have low affinity for CRM1 to function optimally. We previously generated artificial NESs with higher affinities for CRM1, termed supraphysiological NESs. Here we identify a supraphysiological NES in an endogenous protein, the NS2 protein of parvovirus Minute Virus of Mice (MVM). NS2 interacts with CRM1 without the requirement of RanGTP, whereas addition of R ...[more]