Ontology highlight
ABSTRACT:
SUBMITTER: Ossovskaya V
PROVIDER: S-EPMC2547126 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
FEBS letters 20080610 16
Ubiquitously expressed focal adhesion kinase (FAK), a critical component in transducing signals from sites of cell contacts with extracellular matrix, was named after its typical localization in focal adhesions. A nuclear localization of FAK has been also reported and its scaffolding role in nucleus and requirement for p53 ubiquitination were only recently described. Whereas FAK nuclear localization signal (NLS) was found in F2 lobe of FERM domain, nuclear export signal (NES) sequences have not ...[more]