I SA channel complexes include four subunits each of DPP6 and Kv4.2.
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ABSTRACT:
SUBMITTER: Soh H
PROVIDER: S-EPMC2397469 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Publications
I SA channel complexes include four subunits each of DPP6 and Kv4.2.
Soh Heun H Goldstein Steve A N SA
The Journal of biological chemistry 20080325 22
Kv4 potassium channels produce rapidly inactivating currents that regulate excitability of muscles and nerves. To reconstitute the neuronal A-type current I(SA), Kv4 subunits assemble with DPP6, a single transmembrane domain accessory subunit. DPP6 alters function-accelerating activation, inactivation, and recovery from inactivation-and increases surface expression. We sought here to determine the stoichiometry of Kv4 and DPP6 in complexes using functional and biochemical methods. First, wild ty ...[more]
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