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Alu elements and hominid phylogenetics.


ABSTRACT: Alu elements have inserted in primate genomes throughout the evolution of the order. One particular Alu lineage (Ye) began amplifying relatively early in hominid evolution and continued propagating at a low level as many of its members are found in a variety of hominid genomes. This study represents the first conclusive application of short interspersed elements, which are considered nearly homoplasy-free, to elucidate the phylogeny of hominids. Phylogenetic analysis of Alu Ye5 elements and elements from several other subfamilies reveals high levels of support for monophyly of Hominidae, tribe Hominini and subtribe Hominina. Here we present the strongest evidence reported to date for a sister relationship between humans and chimpanzees while clearly distinguishing the chimpanzee and human lineages.

SUBMITTER: Salem AH 

PROVIDER: S-EPMC240696 | biostudies-literature | 2003 Oct

REPOSITORIES: biostudies-literature

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Alu elements and hominid phylogenetics.

Salem Abdel-Halim AH   Ray David A DA   Xing Jinchuan J   Callinan Pauline A PA   Myers Jeremy S JS   Hedges Dale J DJ   Garber Randall K RK   Witherspoon David J DJ   Jorde Lynn B LB   Batzer Mark A MA  

Proceedings of the National Academy of Sciences of the United States of America 20031015 22


Alu elements have inserted in primate genomes throughout the evolution of the order. One particular Alu lineage (Ye) began amplifying relatively early in hominid evolution and continued propagating at a low level as many of its members are found in a variety of hominid genomes. This study represents the first conclusive application of short interspersed elements, which are considered nearly homoplasy-free, to elucidate the phylogeny of hominids. Phylogenetic analysis of Alu Ye5 elements and elem  ...[more]

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