Dataset Information

Airway wall thickness assessed using computed tomography and optical coherence tomography.

ABSTRACT:

Rationale

Computed tomography (CT) has been shown to reliably measure the airway wall dimensions of medium to large airways. Optical coherence tomography (OCT) is a promising new micron-scale resolution imaging technique that can image small airways 2 mm in diameter or less.

Objectives

To correlate OCT measurements of airway dimensions with measurements assessed using CT scans and lung function.

Methods

Forty-four current and former smokers received spirometry, CT scans, and OCT imaging at the time of bronchoscopy. Specific bronchial segments were identified and measured using the OCT images and three-dimensional reconstructions of the bronchial tree using CT.

Measurements and main results

There was a strong correlation between CT and OCT measurements of lumen and wall area (r = 0.84, P < 0.001, and r = 0.89, P < 0.001, respectively). Compared with CT, OCT measurements were lower for both lumen and wall area by 31 and 66%, respectively. The correlation between FEV(1)% predicted and CT and OCT measured wall area (as percentage of the total area) of fifth-generation airways was very strong (r = -0.79, r = -0.75), but the slope of the relationship was much steeper using OCT than using CT (y = -0.33x + 82, y = -0.1x + 78), indicating greater sensitivity of OCT in detecting changes in wall measurements that relate to FEV(1).

Conclusions

OCT can be used to measure airway wall dimensions. OCT may be more sensitive at detecting small airway wall changes that lead to FEV(1) changes in individuals with obstructive airway disease.

SUBMITTER: Coxson HO

PROVIDER: S-EPMC2408438 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature

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Publications

Airway wall thickness assessed using computed tomography and optical coherence tomography.

Coxson Harvey O HO Quiney Brendan B Sin Don D DD Xing Li L McWilliams Annette M AM Mayo John R JR Lam Stephen S

American journal of respiratory and critical care medicine 20080228 11

<h4>Rationale</h4>Computed tomography (CT) has been shown to reliably measure the airway wall dimensions of medium to large airways. Optical coherence tomography (OCT) is a promising new micron-scale resolution imaging technique that can image small airways 2 mm in diameter or less.<h4>Objectives</h4>To correlate OCT measurements of airway dimensions with measurements assessed using CT scans and lung function.<h4>Methods</h4>Forty-four current and former smokers received spirometry, CT scans, an ...[more]

PMID: 18310475

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Dataset Information

Airway wall thickness assessed using computed tomography and optical coherence tomography.

Rationale

Objectives

Methods

Measurements and main results

Conclusions

Publications

Airway wall thickness assessed using computed tomography and optical coherence tomography.

Similar Datasets

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