Ontology highlight
ABSTRACT:
SUBMITTER: Puri V
PROVIDER: S-EPMC2409392 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Puri Vishwajeet V Ranjit Srijana S Konda Silvana S Nicoloro Sarah M C SM Straubhaar Juerg J Chawla Anil A Chouinard My M Lin Chenyi C Burkart Alison A Corvera Silvia S Perugini Richard A RA Czech Michael P MP
Proceedings of the National Academy of Sciences of the United States of America 20080528 22
Storage of energy as triglyceride in large adipose-specific lipid droplets is a fundamental need in all mammals. Efficient sequestration of fat in adipocytes also prevents fatty acid overload in skeletal muscle and liver, which can impair insulin signaling. Here we report that the Cide domain-containing protein Cidea, previously thought to be a mitochondrial protein, colocalizes around lipid droplets with perilipin, a regulator of lipolysis. Cidea-GFP greatly enhances lipid droplet size when ect ...[more]