Ontology highlight
ABSTRACT:
SUBMITTER: Ficara F
PROVIDER: S-EPMC2416441 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Ficara Francesca F Murphy Mark J MJ Lin Min M Cleary Michael L ML
Cell stem cell 20080501 5
Self-renewal is a defining characteristic of stem cells; however, the molecular pathways underlying its regulation are poorly understood. Here, we demonstrate that conditional inactivation of the Pbx1 proto-oncogene in the hematopoietic compartment results in a progressive loss of long-term hematopoietic stem cells (LT-HSCs) that is associated with concomitant reduction in their quiescence, leading to a defect in the maintenance of self-renewal as assessed by serial transplantation. Transcriptio ...[more]