Ontology highlight
ABSTRACT:
SUBMITTER: Frelin C
PROVIDER: S-EPMC4972578 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Frelin Catherine C Herrington Robert R Janmohamed Salima S Barbara Mary M Tran Gary G Paige Christopher J CJ Benveniste Patricia P Zuñiga-Pflücker Juan-Carlos JC Souabni Abdallah A Busslinger Meinrad M Iscove Norman N NN
Nature immunology 20130825 10
The transcription factor GATA-3 is expressed and required for differentiation and function throughout the T lymphocyte lineage. Despite evidence it may also be expressed in multipotent hematopoietic stem cells (HSCs), any role for GATA-3 in these cells has remained unclear. Here we found GATA-3 was in the cytoplasm in quiescent long-term stem cells from steady-state bone marrow but relocated to the nucleus when HSCs cycled. Relocation depended on signaling via the mitogen-activated protein kinas ...[more]