Ontology highlight
ABSTRACT:
SUBMITTER: Yang PH
PROVIDER: S-EPMC2417189 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Yang Pai-Hao PH Cheung William K C WK Peng Ying Y He Ming-Liang ML He Ming-Liang ML Wu Guo-Qing GQ Xie Dan D Jiang Bing-Hua BH Huang Qiu-Hua QH Chen Zhu Z Lin Marie C M MC Kung Hsiang-Fu HF
The Journal of biological chemistry 20080115 13
Makorin-2 belongs to the makorin RING zinc finger gene family, which encodes putative ribonucleoproteins. Here we cloned the Xenopus makorin-2 (mkrn2) and characterized its function in Xenopus neurogenesis. Forced overexpression of mkrn2 produced tadpoles with dorso-posterior deficiencies and small-head/short-tail phenotype, whereas knockdown of mkrn2 by morpholino antisense oligonucleotides induced double axis in tadpoles. In Xenopus animal cap explant assay, mkrn2 inhibited activin, and retino ...[more]