Ontology highlight
ABSTRACT:
SUBMITTER: Via LE
PROVIDER: S-EPMC2423064 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Via Laura E LE Lin P Ling PL Ray Sonja M SM Carrillo Jose J Allen Shannon Sedberry SS Eum Seok Yong SY Taylor Kimberly K Klein Edwin E Manjunatha Ujjini U Gonzales Jacqueline J Lee Eun Gae EG Park Seung Kyu SK Raleigh James A JA Cho Sang Nae SN McMurray David N DN Flynn JoAnne L JL Barry Clifton E CE
Infection and immunity 20080317 6
Understanding the physical characteristics of the local microenvironment in which Mycobacterium tuberculosis resides is an important goal that may allow the targeting of metabolic processes to shorten drug regimens. Pimonidazole hydrochloride (Hypoxyprobe) is an imaging agent that is bioreductively activated only under hypoxic conditions in mammalian tissue. We employed this probe to evaluate the oxygen tension in tuberculous granulomas in four animal models of disease: mouse, guinea pig, rabbit ...[more]