Ontology highlight
ABSTRACT:
SUBMITTER: Wu LP
PROVIDER: S-EPMC2423178 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Wu Li-Peng LP Wang Xi X Li Lian L Zhao Ying Y Lu Shaoli S Yu Yu Y Zhou Wen W Liu Xiangyu X Yang Jing J Zheng Zhixin Z Zhang Hui H Feng Jingnan J Yang Yang Y Wang Haiying H Zhu Wei-Guo WG
Molecular and cellular biology 20080310 10
Histone deacetylase inhibitor (HDACi) has been shown to demethylate the mammalian genome, which further strengthens the concept that DNA methylation and histone modifications interact in regulation of gene expression. Here, we report that an HDAC inhibitor, depsipeptide, exhibited significant demethylating activity on the promoters of several genes, including p16, SALL3, and GATA4 in human lung cancer cell lines H719 and H23, colon cancer cell line HT-29, and pancreatic cancer cell line PANC1. A ...[more]