Ontology highlight
ABSTRACT:
SUBMITTER: Hemminki K
PROVIDER: S-EPMC2423486 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Hemminki Kari K Försti Asta A Bermejo Justo Lorenzo JL
PloS one 20080618 6
The recent large genotyping studies have identified a new repertoire of disease susceptibility loci of unknown function, characterized by high allele frequencies and low relative risks, lending support to the common disease-common variant (CDCV) hypothesis. The variants explain a much larger proportion of the disease etiology, measured by the population attributable fraction, than of the familial risk. We show here that if the identified polymorphisms were markers of rarer functional alleles the ...[more]