Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families.
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ABSTRACT:
SUBMITTER: Gormley P
PROVIDER: S-EPMC5967411 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
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Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families.
Gormley Padhraig P Kurki Mitja I MI Hiekkala Marjo Eveliina ME Veerapen Kumar K Häppölä Paavo P Mitchell Adele A AA Lal Dennis D Palta Priit P Surakka Ida I Kaunisto Mari Anneli MA Hämäläinen Eija E Vepsäläinen Salli S Havanka Hannele H Harno Hanna H Ilmavirta Matti M Nissilä Markku M Säkö Erkki E Sumelahti Marja-Liisa ML Liukkonen Jarmo J Sillanpää Matti M Metsähonkala Liisa L Koskinen Seppo S Lehtimäki Terho T Raitakari Olli O Männikkö Minna M Ran Caroline C Belin Andrea Carmine AC Jousilahti Pekka P Anttila Verneri V Salomaa Veikko V Artto Ville V Färkkilä Markus M Runz Heiko H Daly Mark J MJ Neale Benjamin M BM Ripatti Samuli S Kallela Mikko M Wessman Maija M Palotie Aarno A
Neuron 20180503 4
Complex traits, including migraine, often aggregate in families, but the underlying genetic architecture behind this is not well understood. The aggregation could be explained by rare, penetrant variants that segregate according to Mendelian inheritance or by the sufficient polygenic accumulation of common variants, each with an individually small effect, or a combination of the two hypotheses. In 8,319 individuals across 1,589 migraine families, we calculated migraine polygenic risk scores (PRS ...[more]
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