Ontology highlight
ABSTRACT:
SUBMITTER: Kang S
PROVIDER: S-EPMC2424114 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Kang Sumin S Dong Shaozhong S Gu Ting-Lei TL Guo Ailan A Cohen Michael S MS Lonial Sagar S Khoury Hanna Jean HJ Fabbro Doriano D Gilliland D Gary DG Bergsagel P Leif PL Taunton Jack J Polakiewicz Roberto D RD Chen Jing J
Cancer cell 20070901 3
To better understand the signaling properties of oncogenic FGFR3, we performed phospho-proteomics studies to identify potential downstream signaling effectors that are tyrosine phosphorylated in hematopoietic cells expressing constitutively activated leukemogenic FGFR3 mutants. We found that FGFR3 directly tyrosine phosphorylates the serine/threonine kinase p90RSK2 at Y529, which consequently regulates RSK2 activation by facilitating inactive ERK binding to RSK2 that is required for ERK-dependen ...[more]