Ontology highlight
ABSTRACT:
SUBMITTER: Schwede A
PROVIDER: S-EPMC2425496 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Schwede Angela A Ellis Louise L Luther Julia J Carrington Mark M Stoecklin Georg G Clayton Christine C
Nucleic acids research 20080427 10
The eukaryotic Ccr4/Caf1/Not complex is involved in deadenylation of mRNAs. The Caf1 and Ccr4 subunits both potentially have deadenylating enzyme activity. We investigate here the roles of Ccr4 and Caf1 in deadenylation in two organisms that separated early in eukaryotic evolution: humans and trypanosomes. In Trypanosoma brucei, we found a complex containing CAF1, NOT1, NOT2 and NOT5, DHH1 and a possible homologue of Caf130; no homologue of Ccr4 was found. Trypanosome CAF1 has deadenylation acti ...[more]