Ontology highlight
ABSTRACT:
SUBMITTER: Schwede A
PROVIDER: S-EPMC2760810 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Schwede Angela A Manful Theresa T Jha Bhaskar Anand BA Helbig Claudia C Bercovich Natalia N Stewart Mhairi M Clayton Christine C
Nucleic acids research 20090713 16
Removal of the poly(A) tail is the first step in the degradation of many eukaryotic mRNAs. In metazoans and yeast, the Ccr4/Caf1/Not complex has the predominant deadenylase activity, while the Pan2/Pan3 complex may trim poly(A) tails to the correct size, or initiate deadenylation. In trypanosomes, turnover of several constitutively-expressed or long-lived mRNAs is not affected by depletion of the 5'-3' exoribonuclease XRNA, but is almost completely inhibited by depletion of the deadenylase CAF1. ...[more]