Ontology highlight
ABSTRACT:
SUBMITTER: Tubb MR
PROVIDER: S-EPMC2427326 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Tubb Matthew R MR Silva R A Gangani D RA Fang Jianwen J Tso Patrick P Davidson W Sean WS
The Journal of biological chemistry 20080422 25
Human apolipoprotein A-IV (apoA-IV) is a 46-kDa exchangeable plasma protein with many proposed functions. It is involved in chylomicron assembly and secretion, protection from atherosclerosis through a variety of mechanisms, and inhibition of food intake. There is little structural basis for these proposed functions due to the lack of a solved three-dimensional structure of the protein by x-ray crystallography or NMR. Based on previous studies, we hypothesized that lipid-free apoA-IV exists in a ...[more]