Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC2430334 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
FEMS microbiology letters 20080318 2
Survival of Porphyromonas gingivalis in the constantly changing oral environment depends on its ability to alter gene expression. We demonstrate here that P. gingivalis activates superoxide dismutase expression in response to oxidative stress and represses expression of FimA, a subunit of major fimbriae. Coordinated expression of fimA and sod is regulated by the redox-sensing transcription factor OxyR. Mutations in the oxyR gene result in a decreased expression of sod and in an elevated expressi ...[more]