Ontology highlight
ABSTRACT:
SUBMITTER: Svintradze DV
PROVIDER: S-EPMC3792645 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Acta crystallographica. Section D, Biological crystallography 20130920 Pt 10
OxyR transcriptionally regulates Escherichia coli oxidative stress response genes through a reversibly reducible cysteine disulfide biosensor of cellular redox status. Structural changes induced by redox changes in these cysteines are conformationally transmitted to the dimer subunit interfaces, which alters dimer and tetramer interactions with DNA. In contrast to E. coli OxyR regulatory-domain structures, crystal structures of Porphyromonas gingivalis OxyR regulatory domains show minimal differ ...[more]