Ontology highlight
ABSTRACT:
SUBMITTER: Chen W
PROVIDER: S-EPMC2430522 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Chen Weili W Kumar Ashish R AR Hudson Wendy A WA Li Quanzhi Q Wu Baolin B Staggs Rodney A RA Lund Erik A EA Sam Thien N TN Kersey John H JH
Cancer cell 20080501 5
The pathways by which oncogenes, such as MLL-AF9, initiate transformation and leukemia in humans and mice are incompletely defined. In a study of target cells and oncogene dosage, we found that Mll-AF9, when under endogenous regulatory control, efficiently transformed LSK (Lin(-)Sca1(+)c-kit(+)) stem cells, while committed granulocyte-monocyte progenitors (GMPs) were transformation resistant and did not cause leukemia. Mll-AF9 was expressed at higher levels in hematopoietic stem (HSC) than GMP c ...[more]