Ontology highlight
ABSTRACT:
SUBMITTER: Bindels EM
PROVIDER: S-EPMC3382941 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Bindels Eric M J EM Havermans Marije M Lugthart Sanne S Erpelinck Claudia C Wocjtowicz Elizabeth E Krivtsov Andrei V AV Rombouts Elwin E Armstrong Scott A SA Taskesen Erdogan E Haanstra Jurgen R JR Beverloo H Berna HB Döhner Hartmut H Hudson Wendy A WA Kersey John H JH Delwel Ruud R Kumar Ashish R AR
Blood 20120502 24
The proto-oncogene EVI1 (ecotropic viral integration site-1), located on chromosome band 3q26, is aberrantly expressed in human acute myeloid leukemia (AML) with 3q26 rearrangements. In the current study, we showed, in a large AML cohort carrying 11q23 translocations, that ∼ 43% of all mixed lineage leukemia (MLL)-rearranged leukemias are EVI1(pos). High EVI1 expression occurs in AMLs expressing the MLL-AF6, -AF9, -AF10, -ENL, or -ELL fusion genes. In addition, we present evidence that EVI1(pos) ...[more]