Ontology highlight
ABSTRACT:
SUBMITTER: Ruddell A
PROVIDER: S-EPMC2435006 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Ruddell Alanna A Harrell Maria I MI Minoshima Satoshi S Maravilla Kenneth R KR Iritani Brian M BM White Steven W SW Partridge Savannah C SC
Neoplasia (New York, N.Y.) 20080701 7
The growth of metastatic tumors in mice can result in markedly increased lymph flow through tumor-draining lymph nodes (LNs), which is associated with LN lymphangiogenesis. A dynamic magnetic resonance imaging (MRI) assay was developed, which uses low-molecular weight gadolinium contrast agent to label the lymphatic drainage, to visualize and quantify tumor-draining lymph flow in vivo in mice bearing metastatic melanomas. Tumor-bearing mice showed greatly increased lymph flow into and through dr ...[more]