Ontology highlight
ABSTRACT:
SUBMITTER: Mallari JP
PROVIDER: S-EPMC2435229 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20080408 9
Human African trypanosomiasis (HAT) is caused by the protozoan parasite Trypanosoma brucei. The cysteine proteases of T. brucei have been shown to be crucial for parasite replication and represent an attractive point for therapeutic intervention. Herein we describe the synthesis of a series of thiosemicarbazones and their activity against the trypanosomal cathepsins TbcatB and rhodesain, as well as human cathepsins L and B. The activity of these compounds was determined against cultured T. bruce ...[more]