Evidence for insulin suppression of baseline luteinizing hormone in women with polycystic ovarian syndrome and normal women.

ABSTRACT:

Context

In women with polycystic ovarian syndrome (PCOS), the relationship of insulin to LH secretion and responses to GnRH remains unresolved. A rigorous analytical examination of this relationship has not been performed.

Objective

Our objective was to determine the relationship of basal LH secretion and responses to GnRH, insulin, and other endocrine variables in normal and PCOS women.

Design

In PCOS and normal women, mean composite 12-h LH secretion was analyzed for correlating factors. LH responses to varying doses of GnRH during a fixed rate of insulin infusion and LH responses to a fixed dose of GnRH during varying doses of insulin infusion were analyzed for contributing factors.

Patients and setting

Eighteen PCOS and 21 normal women underwent studies of

SUBMITTER: Lawson MA 

PROVIDER: S-EPMC2435648 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature