Sequence-based prediction of protein-protein interactions by means of codon usage.
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ABSTRACT:
SUBMITTER: Najafabadi HS
PROVIDER: S-EPMC2441473 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Publications
Sequence-based prediction of protein-protein interactions by means of codon usage.
Najafabadi Hamed Shateri HS Salavati Reza R
Genome biology 20080523 5
We introduce a novel approach to predict interaction of two proteins solely by analyzing their coding sequences. We found that similarity in codon usage is a strong predictor of protein-protein interactions and, for high specificity values, is as sensitive as the most powerful current prediction methods. Furthermore, combining codon usage with other predictors results in a 75% increase in sensitivity at a precision of 50%, compared to prediction without considering codon usage. ...[more]
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