Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC2441565 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Yang Yizeng Y Tetreault Marie-Pier MP Yermolina Yuliya A YA Goldstein Bree G BG Katz Jonathan P JP
The Journal of biological chemistry 20080501 27
Migration of epithelial cells is critical for normal homeostasis in gut and skin, but the factors regulating this process are not completely understood. The zinc finger transcription factor Klf5 (IKLF; BTEB2) is highly expressed in proliferating cells of esophagus, skin, and other organs. We hypothesized that Klf5 regulates keratinocyte migration via the integrin-linked kinase (ILK), which, like Klf5, is localized to basal keratinocytes. We stably transduced mouse primary esophageal keratinocyte ...[more]