Ontology highlight
ABSTRACT:
SUBMITTER: Barr VA
PROVIDER: S-EPMC2441672 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Barr Valarie A VA Bernot Kelsie M KM Srikanth Sonal S Gwack Yousang Y Balagopalan Lakshmi L Regan Carole K CK Helman Daniel J DJ Sommers Connie L CL Oh-Hora Masatsugu M Rao Anjana A Samelson Lawrence E LE
Molecular biology of the cell 20080430 7
The proteins STIM1 and Orai1 are the long sought components of the store-operated channels required in T-cell activation. However, little is known about the interaction of these proteins in T-cells after engagement of the T-cell receptor. We found that T-cell receptor engagement caused STIM1 and Orai1 to colocalize in puncta near the site of stimulation and accumulate in a dense structure on the opposite side of the T-cell. FRET measurements showed a close interaction between STIM1 and Orai1 bot ...[more]