Ontology highlight
ABSTRACT:
SUBMITTER: Gusarov I
PROVIDER: S-EPMC2442334 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Gusarov Ivan I Starodubtseva Marina M Wang Zhi-Qiang ZQ McQuade Lindsey L Lippard Stephen J SJ Stuehr Dennis J DJ Nudler Evgeny E
The Journal of biological chemistry 20080303 19
Bacterial nitric-oxide (NO) synthases (bNOSs) are smaller than their mammalian counterparts. They lack an essential reductase domain that supplies electrons during NO biosynthesis. This and other structural peculiarities have raised doubts about whether bNOSs were capable of producing NO in vivo. Here we demonstrate that bNOS enzymes from Bacillus subtilis and Bacillus anthracis do indeed produce NO in living cells and accomplish this task by hijacking available cellular redox partners that are ...[more]