Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC4188008 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Li Huiying H Jamal Joumana J Plaza Carla C Pineda Stephanie Hai SH Chreifi Georges G Jing Qing Q Cinelli Maris A MA Silverman Richard B RB Poulos Thomas L TL
Acta crystallographica. Section D, Biological crystallography 20140927 Pt 10
Mammals produce three isoforms of nitric oxide synthase (NOS): neuronal NOS (nNOS), inducible NOS (iNOS) and endothelial NOS (eNOS). The overproduction of NO by nNOS is associated with a number of neurodegenerative disorders; therefore, a desirable therapeutic goal is the design of drugs that target nNOS but not the other isoforms. Crystallography, coupled with computational approaches and medicinal chemistry, has played a critical role in developing highly selective nNOS inhibitors that exhibit ...[more]