Ontology highlight
ABSTRACT:
SUBMITTER: Hallas C
PROVIDER: S-EPMC24451 | biostudies-literature | 1999 Dec
REPOSITORIES: biostudies-literature
Hallas C C Pekarsky Y Y Itoyama T T Varnum J J Bichi R R Rothstein J L JL Croce C M CM
Proceedings of the National Academy of Sciences of the United States of America 19991201 25
TCL1 and TCL1b genes on human chromosome 14q23.1 are activated in T cell leukemias by translocations and inversions at 14q32.1, juxtaposing them to regulatory elements of T cell receptor genes. In this report we present the cloning, mapping, and expression analysis of the human and murine TCL1/Tcl1 locus. In addition to TCL1 and TCL1b, the human locus contains two additional genes, TCL1-neighboring genes (TNG) 1 and 2, encoding proteins of 141 and 110 aa, respectively. Both genes show no homolog ...[more]