Ontology highlight
ABSTRACT:
SUBMITTER: Dai MS
PROVIDER: S-EPMC2447154 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Dai Mu-Shui MS Sun Xiao-Xin XX Lu Hua H
Molecular and cellular biology 20080421 13
The nucleolar protein nucleostemin (NS) is essential for cell proliferation and early embryogenesis. Both depletion and overexpression of NS reduce cell proliferation. However, the mechanisms underlying this regulation are still unclear. Here, we show that NS regulates p53 activity through the inhibition of MDM2. NS binds to the central acidic domain of MDM2 and inhibits MDM2-mediated p53 ubiquitylation and degradation. Consequently, ectopic overexpression of NS activates p53, induces G(1) cell ...[more]