KFC Server: interactive forecasting of protein interaction hot spots.
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ABSTRACT:
SUBMITTER: Darnell SJ
PROVIDER: S-EPMC2447760 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Publications
KFC Server: interactive forecasting of protein interaction hot spots.
Darnell Steven J SJ LeGault Laura L Mitchell Julie C JC
Nucleic acids research 20080606 Web Server issue
The KFC Server is a web-based implementation of the KFC (Knowledge-based FADE and Contacts) model-a machine learning approach for the prediction of binding hot spots, or the subset of residues that account for most of a protein interface's; binding free energy. The server facilitates the automated analysis of a user submitted protein-protein or protein-DNA interface and the visualization of its hot spot predictions. For each residue in the interface, the KFC Server characterizes its local struct ...[more]
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