Ontology highlight
ABSTRACT:
SUBMITTER: Wayman GA
PROVIDER: S-EPMC2449370 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Wayman Gary A GA Davare Monika M Ando Hideaki H Fortin Dale D Varlamova Olga O Cheng Hai-Ying M HY Marks Daniel D Obrietan Karl K Soderling Thomas R TR Goodman Richard H RH Impey Soren S
Proceedings of the National Academy of Sciences of the United States of America 20080624 26
Activity-regulated gene expression is believed to play a key role in the development and refinement of neuronal circuitry. Nevertheless, the transcriptional networks that regulate synapse growth and plasticity remain largely uncharacterized. Here, we show that microRNA 132 (miR132) is an activity-dependent rapid response gene regulated by the cAMP response element-binding (CREB) protein pathway. Introduction of miR132 into hippocampal neurons enhanced dendrite morphogenesis whereas inhibition of ...[more]