Ontology highlight
ABSTRACT:
SUBMITTER: Otto CM
PROVIDER: S-EPMC2459256 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Otto Cynthia M CM Markstaller Klaus K Kajikawa Osamu O Karmrodt Jens J Syring Rebecca S RS Pfeiffer Birgit B Good Virginia P VP Frevert Charles W CW Baumgardner James E JE
Journal of applied physiology (Bethesda, Md. : 1985) 20080306 5
Volutrauma and atelectrauma have been proposed as mechanisms of ventilator-associated lung injury, but few studies have compared their relative importance in mediating lung injury. The objective of our study was to compare the injury produced by stretch (volutrauma) vs. cyclical recruitment (atelectrauma) after surfactant depletion. In saline-lavaged rabbits, we used high tidal volume, low respiratory rate, and low positive end-expiratory pressure to produce stretch injury in nondependent lung r ...[more]