Spemann's organizer and self-regulation in amphibian embryos.
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ABSTRACT:
SUBMITTER: De Robertis EM
PROVIDER: S-EPMC2464568 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Publications
Spemann's organizer and self-regulation in amphibian embryos.
Nature reviews. Molecular cell biology 20060401 4
In 1924, Spemann and Mangold demonstrated the induction of Siamese twins in transplantation experiments with salamander eggs. Recent work in amphibian embryos has followed their lead and uncovered that cells in signalling centres that are located at the dorsal and ventral poles of the gastrula embryo communicate with each other through a network of secreted growth-factor antagonists, a protease that degrades them, a protease inhibitor and bone-morphogenic-protein signals. ...[more]
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