The establishment of Spemann's organizer and patterning of the vertebrate embryo.
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ABSTRACT:
SUBMITTER: De Robertis EM
PROVIDER: S-EPMC2291143 | biostudies-literature | 2000 Dec
REPOSITORIES: biostudies-literature
Publications
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
De Robertis E M EM Larraín J J Oelgeschläger M M Wessely O O
Nature reviews. Genetics 20001201 3
Molecular studies have begun to unravel the sequential cell-cell signalling events that establish the dorsal-ventral, or 'back-to-belly', axis of vertebrate animals. In Xenopus and zebrafish, these events start with the movement of membrane vesicles associated with dorsal determinants. This mediates the induction of mesoderm by generating gradients of growth factors. Dorsal mesoderm then becomes a signalling centre, the Spemann's organizer, which secretes several antagonists of growth-factor sig ...[more]
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