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Comparison of parametric and nonparametric methods to map oligogenes by linkage.

ABSTRACT: A sample of 95 sib pairs affected with insulin-dependent diabetes and typed with their normal parents for 28 markers on chromosome 6 has been analyzed by several methods. When appropriate parameters are efficiently estimated, a parametric model is equivalent to the beta model, which is superior to nonparametric alternatives both in single point tests (as found previously) and in multipoint tests. Theory is given for meta-analysis combined with allelic association, and problems that may be associated with errors of map location and/or marker typing are identified. Reducing by multipoint analysis the number of association tests in a dense map can give a 3-fold reduction in the critical lod, and therefore in the cost of positional cloning.

SUBMITTER: Lio P

PROVIDER: S-EPMC24680 | biostudies-literature | 1997 May

REPOSITORIES: biostudies-literature

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Comparison of parametric and nonparametric methods to map oligogenes by linkage.

Liò P P Morton N E NE

Proceedings of the National Academy of Sciences of the United States of America 19970501 10

A sample of 95 sib pairs affected with insulin-dependent diabetes and typed with their normal parents for 28 markers on chromosome 6 has been analyzed by several methods. When appropriate parameters are efficiently estimated, a parametric model is equivalent to the beta model, which is superior to nonparametric alternatives both in single point tests (as found previously) and in multipoint tests. Theory is given for meta-analysis combined with allelic association, and problems that may be associ ...[more]

PMID: 9144239

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