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Effect of linkage geometry on biological activity in thiourea- and guanidine-substituted acridines and platinum-acridines.

ABSTRACT: Novel thiourea- and guanidine-modified acridine-4-carboxamides (4, 7) and a corresponding platinum-intercalator conjugate (4') have been synthesized and evaluated as cytotoxic agents in human promyelocytic leukemia, HL-60, and a non-small cell lung cancer, NCI-H460. Modification of thiourea sulfur in derivative 4 with a DNA platinating moiety, giving 4', resulted in a pronounced cytotoxic enhancement, and the conjugate proved to be the most active of the newly synthesized compounds in NCI-H460 cells. Conjugate 4' represents a new chemotype with potential applications in the treatment of chemoresistant tumors.

SUBMITTER: Ma Z

PROVIDER: S-EPMC2474763 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature

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Effect of linkage geometry on biological activity in thiourea- and guanidine-substituted acridines and platinum-acridines.

Ma Zhidong Z Saluta Gilda G Kucera Gregory L GL Bierbach Ulrich U

Bioorganic & medicinal chemistry letters 20080516 13

Novel thiourea- and guanidine-modified acridine-4-carboxamides (4, 7) and a corresponding platinum-intercalator conjugate (4') have been synthesized and evaluated as cytotoxic agents in human promyelocytic leukemia, HL-60, and a non-small cell lung cancer, NCI-H460. Modification of thiourea sulfur in derivative 4 with a DNA platinating moiety, giving 4', resulted in a pronounced cytotoxic enhancement, and the conjugate proved to be the most active of the newly synthesized compounds in NCI-H460 c ...[more]

PMID: 18515101

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