Ontology highlight
ABSTRACT:
SUBMITTER: Kulic IM
PROVIDER: S-EPMC2481308 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Kulic Igor M IM Brown André E X AE Kim Hwajin H Kural Comert C Blehm Benjamin B Selvin Paul R PR Nelson Philip C PC Gelfand Vladimir I VI
Proceedings of the National Academy of Sciences of the United States of America 20080714 29
We study the role of microtubule movement in bidirectional organelle transport in Drosophila S2 cells and show that EGFP-tagged peroxisomes in cells serve as sensitive probes of motor induced, noisy cytoskeletal motions. Multiple peroxisomes move in unison over large time windows and show correlations with microtubule tip positions, indicating rapid microtubule fluctuations in the longitudinal direction. We report the first high-resolution measurement of longitudinal microtubule fluctuations per ...[more]