Ontology highlight
ABSTRACT:
SUBMITTER: Hendgen-Cotta UB
PROVIDER: S-EPMC2481313 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Hendgen-Cotta Ulrike B UB Merx Marc W MW Shiva Sruti S Schmitz Joel J Becher Stefanie S Klare Johann P JP Steinhoff Heinz-Jürgen HJ Goedecke Axel A Schrader Jürgen J Gladwin Mark T MT Kelm Malte M Rassaf Tienush T
Proceedings of the National Academy of Sciences of the United States of America 20080716 29
The nitrite anion is reduced to nitric oxide (NO*) as oxygen tension decreases. Whereas this pathway modulates hypoxic NO* signaling and mitochondrial respiration and limits myocardial infarction in mammalian species, the pathways to nitrite bioactivation remain uncertain. Studies suggest that hemoglobin and myoglobin may subserve a fundamental physiological function as hypoxia dependent nitrite reductases. Using myoglobin wild-type ((+/+)) and knockout ((-/-)) mice, we here test the central rol ...[more]