Ontology highlight
ABSTRACT:
SUBMITTER: Shukla AK
PROVIDER: S-EPMC2481318 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Shukla Arun K AK Violin Jonathan D JD Whalen Erin J EJ Gesty-Palmer Diane D Shenoy Sudha K SK Lefkowitz Robert J RJ
Proceedings of the National Academy of Sciences of the United States of America 20080711 29
Beta-arrestins critically regulate G protein-coupled receptors (GPCRs), also known as seven-transmembrane receptors (7TMRs), both by inhibiting classical G protein signaling and by initiating distinct beta-arrestin-mediated signaling. The recent discovery of beta-arrestin-biased ligands and receptor mutants has allowed characterization of these independent "G protein-mediated" and "beta-arrestin-mediated" signaling mechanisms of 7TMRs. However, the molecular mechanisms underlying the dual functi ...[more]