Ontology highlight
ABSTRACT:
SUBMITTER: Rakesh K
PROVIDER: S-EPMC2981501 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Rakesh Kriti K Yoo ByungSu B Kim Il-Man IM Salazar Natasha N Kim Ki-Seok KS Rockman Howard A HA
Science signaling 20100608 125
beta-Arrestins, which were originally characterized as terminators of heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) signaling, also act as important signal transducers. An emerging concept in GPCR signaling is beta-arrestin-biased agonism, in which specific ligand-activated GPCR conformational states selectively signal through beta-arrestins, rather than through G proteins. Here, we show that mechanical stretch induced beta-arrestin-biased signaling downst ...[more]