Ontology highlight
ABSTRACT:
SUBMITTER: Lorenzen MD
PROVIDER: S-EPMC2481321 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Lorenzen Marcé D MD Gnirke Andreas A Margolis Jonathan J Garnes Jeffrey J Campbell Margie M Stuart Jeffrey J JJ Aggarwal Rajat R Richards Stephen S Park Yoonseong Y Beeman Richard W RW
Proceedings of the National Academy of Sciences of the United States of America 20080711 29
Maternal-Effect Dominant Embryonic Arrest ("Medea") factors are selfish nuclear elements that combine maternal-lethal and zygotic-rescue activities to gain a postzygotic survival advantage. We show that Medea(1) activity in Tribolium castaneum is associated with a composite Tc1 transposon inserted just downstream of the neurotransmitter reuptake symporter bloated tubules (blot), whose Drosophila ortholog has both maternal and zygotic functions. The 21.5-kb insertion contains defective copies of ...[more]