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The maternal-effect, selfish genetic element Medea is associated with a composite Tc1 transposon.


ABSTRACT: Maternal-Effect Dominant Embryonic Arrest ("Medea") factors are selfish nuclear elements that combine maternal-lethal and zygotic-rescue activities to gain a postzygotic survival advantage. We show that Medea(1) activity in Tribolium castaneum is associated with a composite Tc1 transposon inserted just downstream of the neurotransmitter reuptake symporter bloated tubules (blot), whose Drosophila ortholog has both maternal and zygotic functions. The 21.5-kb insertion contains defective copies of elongation initiation factor-3, ATP synthase subunit C, and an RNaseD-related gene, as well as a potentially intact copy of a prokaryotic DUF1703 gene. Sequence comparisons suggest that the current distribution of Medea(1) reflects global emanation after a single transpositional event in recent evolutionary time. The Medea system in Tribolium represents an unusual type of intragenomic conflict and could provide a useful vehicle for driving desirable genes into populations.

SUBMITTER: Lorenzen MD 

PROVIDER: S-EPMC2481321 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature

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The maternal-effect, selfish genetic element Medea is associated with a composite Tc1 transposon.

Lorenzen MarcĂ© D MD   Gnirke Andreas A   Margolis Jonathan J   Garnes Jeffrey J   Campbell Margie M   Stuart Jeffrey J JJ   Aggarwal Rajat R   Richards Stephen S   Park Yoonseong Y   Beeman Richard W RW  

Proceedings of the National Academy of Sciences of the United States of America 20080711 29


Maternal-Effect Dominant Embryonic Arrest ("Medea") factors are selfish nuclear elements that combine maternal-lethal and zygotic-rescue activities to gain a postzygotic survival advantage. We show that Medea(1) activity in Tribolium castaneum is associated with a composite Tc1 transposon inserted just downstream of the neurotransmitter reuptake symporter bloated tubules (blot), whose Drosophila ortholog has both maternal and zygotic functions. The 21.5-kb insertion contains defective copies of  ...[more]

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