Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype.
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ABSTRACT:
SUBMITTER: Lobenhofer EK
PROVIDER: S-EPMC2481421 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Publications
Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype.
Lobenhofer Edward K EK Auman J Todd JT Blackshear Pamela E PE Boorman Gary A GA Bushel Pierre R PR Cunningham Michael L ML Fostel Jennifer M JM Gerrish Kevin K Heinloth Alexandra N AN Irwin Richard D RD Malarkey David E DE Merrick B Alex BA Sieber Stella O SO Tucker Charles J CJ Ward Sandra M SM Wilson Ralph E RE Hurban Patrick P Tennant Raymond W RW Paules Richard S RS
Genome biology 20080620 6
This report details the standardized experimental design and the different data streams that were collected (histopathology, clinical chemistry, hematology and gene expression from the target tissue (liver) and a bio-available tissue (blood)) after treatment with eight known hepatotoxicants (at multiple time points and doses with multiple biological replicates). The results of the study demonstrate the classification of histopathological differences, likely reflecting differences in mechanisms o ...[more]
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