Ontology highlight
ABSTRACT:
SUBMITTER: Fang J
PROVIDER: S-EPMC2481541 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Fang Jing J Menon Madhu M Zhang Diya D Torbett Bruce B Oxburgh Leif L Tschan Mario M Houde Estelle E Wojchowski Don M DM
Blood 20080605 3
The adult erythron is maintained via dynamic modulation of erythroblast survival potentials. Toward identifying novel regulators of this process, murine splenic erythroblasts at 3 developmental stages were prepared, purified and profiled. Stage-to-stage modulated genes were then functionally categorized, with a focus on apoptotic factors. In parallel with BCL-X and NIX, death-associated protein kinase-2 (DAPK2) was substantially up-modulated during late erythropoiesis. Among hematopoietic lineag ...[more]