Ontology highlight
ABSTRACT:
SUBMITTER: Lombardi M
PROVIDER: S-EPMC2483513 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Lombardi Maria M Castoria Gabriella G Migliaccio Antimo A Barone Maria Vittoria MV Di Stasio Rosina R Ciociola Alessandra A Bottero Daniela D Yamaguchi Hiroshi H Appella Ettore E Auricchio Ferdinando F
The Journal of cell biology 20080721 2
In breast cancer cells, cytoplasmic localization of the estradiol receptor alpha (ERalpha) regulates estradiol-dependent S phase entry. We identified a nuclear export sequence (NES) in ERalpha and show that its export is dependent on both estradiol-mediated phosphatidylinositol-3-kinase (PI3K)/AKT activation and chromosome region maintenance 1 (CRM1). A Tat peptide containing the ERalpha NES disrupts ERalpha-CRM1 interaction and prevents nuclear export of ERalpha- and estradiol-induced DNA synth ...[more]