Ontology highlight
ABSTRACT:
SUBMITTER: Correll CC
PROVIDER: S-EPMC24837 | biostudies-literature | 1998 Nov
REPOSITORIES: biostudies-literature
Correll C C CC Munishkin A A Chan Y L YL Ren Z Z Wool I G IG Steitz T A TA
Proceedings of the National Academy of Sciences of the United States of America 19981101 23
The structure of a 29-nucleotide RNA containing the sarcin/ricin loop (SRL) of rat 28 S rRNA has been determined at 2.1 A resolution. Recognition of the SRL by elongation factors and by the ribotoxins, sarcin and ricin, requires a nearly universal dodecamer sequence that folds into a G-bulged cross-strand A stack and a GAGA tetraloop. The juxtaposition of these two motifs forms a distorted hairpin structure that allows direct recognition of bases in both grooves as well as recognition of nonheli ...[more]