Ontology highlight
ABSTRACT:
SUBMITTER: Fernandes H
PROVIDER: S-EPMC6057467 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Fernandes Humberto H Czapinska Honorata H Grudziaz Katarzyna K Bujnicki Janusz M JM Nowacka Martyna M
PeerJ 20180704
Acinus is an abundant nuclear protein involved in apoptosis and splicing. It has been implicated in inducing apoptotic chromatin condensation and DNA fragmentation during programmed cell death. Acinus undergoes activation by proteolytic cleavage that produces a truncated p17 form that comprises only the RNA recognition motif (RRM) domain. We have determined the crystal structure of the human Acinus RRM domain (AcRRM) at 1.65 Å resolution. It shows a classical four-stranded antiparallel β-sheet f ...[more]